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Cdh1/APC is involved in lens differentiation. (A) Selection of stable Cdh1 siRNA clones in alpha TN4 cells. (B) Knockdown of Cdh1 by siRNA attenuates SnoN degradation and p21 and p15 accumulation. (C) Quantification of the protein levels for SnoN, p21, and p15 during lens differentiation. (D) Knockdown of Cdh1 significantly blocked lentoid formation. The number of lentoids comprising more than 30 cells were counted.
