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. Author manuscript; available in PMC: 2007 Feb 27.
Published in final edited form as: Anesth Analg. 2006 May;102(5):1485–1490. doi: 10.1213/01.ane.0000204318.35194.ed

Figure 1.

Figure 1

Effect of intrathecal (i.t.) 20 μL of TMB-8 (46 nmol), Quin-2 (1.8 nmol), EGTA-am (0.1 μmol), and EGTA (0.1 μmol) versus the respective vehicles on the responses of paclitaxel- and vincristine-treated rats to von Frey hairs (VFH) exerting 4 g (mechano-allodynia) and 15 g (mechano-hyperalgesia) of force. Data from paclitaxel- and vincristine-treated rats were analyzed separately. The dotted lines indicate baseline values before chemotherapy treatment (mean of all groups combined). There was no difference in response to 4-g and 15-g VFH for both chemotherapy-treated groups after i.t. N/S. For the purpose of graphic presentation, results from paclitaxel- and vincristine-treated rats given i.t. N/S were combined and labeled as “Control”. N/S = normal saline; DMSO+P = 20% Pluronic F-127 in dimethyl sulfoxide (the vehicle for EGTA-am). *P < 0.05; **P < 0.01; n = 10 per group.