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. 2007 Feb 27;104(10):3984–3989. doi: 10.1073/pnas.0700191104

Fig. 1.

Fig. 1.

Activated iNKT cells help antibody responses to bacterial and viral proteins in vivo. Groups of four to six mice were immunized twice (arrows) with the indicated proteins, given alone (□) or with αGC (■). (A) GMTs (and 95% C.I.) of circulating antigen-specific antibodies in C57BL/6 WT mice immunized with TT or DT with or without αGC. (B) GMTs and 95% C.I. of antigen-specific antibodies in sera from C57BL/6 mice bearing (Jα18+/+) or lacking (Jα18−/−) iNKT cells, immunized with H3N2 or H3N2 plus αGC. Results are from one experiment of six (TT), two (DT), or four (H3N2). Asterisks indicate statistically different values between mice immunized with the protein alone and mice immunized with the protein and αGC (∗, P < 0.05; ∗∗, P < 0.01).