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. 2007 Feb 27;104(10):3984–3989. doi: 10.1073/pnas.0700191104

Fig. 2.

Fig. 2.

Activated iNKT cells help T-dependent antibody responses like conventional adjuvants and can substitute for MHC-II-restricted T lymphocytes. (A) IgG1 and IgG2a subclass distribution of circulating TT-specific antibodies in C57BL/6 mice 2 weeks after two immunizations with increasing doses of TT alone, TT plus αGC, TT plus Alum, TT plus CpG, TT plus complete Freund's adjuvant (CFA)/incomplete Freund's adjuvant (IFA). (B) GMTs and 95% C.I. of H3N2-specific IgG in sera from C57BL/6 MHC-II−/− mice 2 weeks after two immunizations with H3N2 alone, H3N2 plus Alum, or H3N2 plus αGC. Results are from one experiment representative of three, in which 3–10 mice per group were tested. Asterisks indicate statistically different values between mice immunized with the protein alone and mice immunized with the protein and the given adjuvant (∗, P < 0.05; ∗∗, P < 0.01).