Table 1.
Tumorigenicity in nude mice
| Genotype | Tumor size (length × width × height), mm |
|---|---|
| WT | ND |
| ND | |
| ND | |
| ND | |
| ND | |
| ND | |
| Irf5−/− | 8 × 8 × 1 |
| 12 × 9 × 1 | |
| 12 × 5 × 1 | |
| 10 × 7 × 1 | |
| 9 × 9 × 4 | |
| 8 × 8 × 4 | |
| Trp53−/− | 23 × 18 × 16 |
| 28 × 24 × 15 | |
| 25 × 14 × 13 |
WT, IRF5−/−, and Trp53−/− MEFs were infected with pGDV12ras retrovirus. Two days after infection, 1 × 106 MEFs were injected s.c. to nude mice to test the tumorigenicity of the cells. Tumor size was determined by caliper measurements after 4 weeks of injection. ND, not detected.