Table 1.
Functional clustering of genes modulated by FOXL2 with mean fold induction/repression ≥2
| Cluster | Gene symbol | Description | Chip fold change | qPCR fold change |
|---|---|---|---|---|
| Chemokine | CCL3L1, 3 | Chemokine (c-c motif) ligand 3-like 1 and 3 | 3.31/2.96 | |
| CCL20 | Chemokine (c-c motif) ligand 20 | 2.43 | ||
| CXCL2 | Chemokine (c-x-c motif) ligand 2 | 2.58 | ||
| CCL3 | Chemokine (c-c motif) ligand 3 | 3.37 | 5.79 | |
| CXCL3 | Chemokine (c-x-c motif) ligand 3 | 2.63 | 3.00 | |
| Apoptosis-related | IER3 | Immediate early response 3 | 2.20 | 4.06 |
| BCL2A1 | bcl2-related protein a1 | 2.51 | 1.52 | |
| PPP1R15A | Protein phosphatase 1, regulatory (inhibitor) subunit 15a | 2.18 | 2.24 | |
| SERPINB2 | Serpin peptidase inhibitor, clade b (ovalbumin), member 2 | 3.10 | 2.11 | |
| Protease | CPM | Carboxypeptidase m | 2.09 | |
| MMP23 | Matrix metallopeptidase 23a | −2.05 | ||
| PRTN3 | Proteinase 3 (serine proteinase) | −2.13 | ||
| KLK9 | Kallikrein 9 | −2.19 | ||
| Signal transduction | HRH2 | Histamine receptor h2 | −2.32 | |
| RLN3L1 | Relaxin 3 receptor 1 | −2.03 | ||
| MRGPRE | mas-related gpr, member e | −2.36 | ||
| GPRC5B | G protein-coupled receptor, family c, group 5, member b | 2.01 | ||
| AVPR2 | Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) | −2.17 | ||
| TAS2R13 | Taste receptor, type 2, member 13 | −2.01 | ||
| Trnscription factor | SSX2 | Synovial sarcoma, x breakpoint 2 | 2.09 | |
| NFAC2 | Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 2 | 2.06 | 2.77 | |
| TNFAIP3 | TNF-α-induced protein 3 | 2.08 | 3.04 | |
| NR5A2 | Nuclear receptor subfamily 5, group a, member 2 | 2.02 | 2.15 | |
| ATF3 | Activating transcription factor 3 | 2.47 | 3.78 | |
| SMAD6 | smad, mothers against dpp homolog 6 (Drosophila) | −2.29 | ||
| ZNF165 | Zinc finger protein 165 | 2.32 | ||
| NR4A3 | Nuclear receptor subfamily 4, group a, member 3 | 2.12 | 2.54 | |
| SOX4 | sry (sex determining region y)-box 4 | 3.18 | ||
| MAFF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) | 2.09 | 4.03 | |
| TCEB3B | Transcription elongation factor b polypeptide 3b (elongin a2) | 2.24 | ||
| EN2 | Engrailed homolog 2 | −2.44 | ||
| SOD2 | Superoxide dismutase 2, mitochondrial | 2.08 | 2.27 | |
| Nonclustered | PTGS2 | Prostaglandin–endoperoxide synthase 2 | 4.29 | 6.27 |
| FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | 3.00 | 3.01 | |
| IFNB1 | Interferon, β1, fibroblast | 2.67 | ||
| IL29 | IL-29 (interferon, λ1) | 2.54 | 3.19 | |
| RGS2 | Regulator of G-protein signalling 2 | 2.42 | 2.53 | |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | 2.41 | ||
| PPARGC1A | Peroxisome proliferative activated receptor-γ coactivator 1α | 2.34 | 3.62 | |
| CH25H | Cholesterol 25-hydroxylase | 2.28 | 2.88 | |
| LIF | Leukemia inhibitory factor | 2.26 | 2.85 | |
| SPRY1 | Sprouty homolog 1, antagonist of FGF signaling | 2.19 | 2.44 | |
| ICAM1 | Intercellular adhesion molecule 1 | 2.16 | 3.92 | |
| OSR2 | Odd-skipped related 2 | 2.13 | 2.81 | |
| PTHLH | Parathyroid hormone-like hormone | 2.09 | 2.06 | |
| IL11 | IL-11 | 2.08 | 3.16 | |
| RSPO3 | R-spondin 3 homolog (Xenopus laevis) | 2.02 | 2.91 | |
| AMH | Anti-Mullerian hormone | −2.24 |
Minus indicates repression. qPCR results represent the mean of three independent experiments. An exhaustive list is provided in SI Table 2.