Fig. 2.

Effect of androgen receptor deficiency and dihydrotestosterone treatment on gonocyte proliferation. Pregnant females (15.5 or 16.5 dpc) were injected with BrdU 3 h before being killed. (A and B) The percentages of BrdU-positive gonocytes (A) and gonocyte mitotic figures (B) were determined from at least 1,000 counted gonocytes. (C) Testes were explanted at 13.5 dpc and treated (or not) for 30 h with dihydrotestosterone (10⁻⁶ M). The percentages of BrdU-positive gonocytes were determined from at least 1,000 counted gonocytes. Values are means ± SEM; ∗, P < 0.05 in Student's t test (A and B; n = 5) or in a paired Student's t test (C; n = 7).