Table 1.
Summary of gene expression profiles in t(1;19) vs. non-t(1;19) human leukemias
| RNA | Type of leukemia | Gene function
|
|||||
|---|---|---|---|---|---|---|---|
| WNT-16 | RZR-β | PKC-ξ | FAT | EphA3 | IRX-related | ||
| Intercellular signaling molecule | Nuclear receptor for melatonin | Serine/threonine protein kinase | Cadherin-related cell adhesion molecule | Receptor protein tyrosine kinase | TALE homeo domain protein | ||
| 697 | t(1;19) pre-B-ALL | + | + | + | + | + | + |
| KOPN-36 | t(1:19) pre-B-ALL | + | + | + | + | + | + |
| KOPN-54 | t(1;19) pre-B-ALL | + | + | + | + | + | − |
| KOPN-63 | t(1;10) pre-B-ALL | + | + | + | + | + | + |
| Reh | Non-t(1;19) pre-B-ALL | − | − | − | − | − | − |
| Nalm-6 | Non-t(1;19) pre-B-ALL | − | − | − | − | − | − |
| Namalwa | Burkitt’s lymphoma | − | − | − | − | − | − |
| Raji | Burkitt’s lymphoma | − | − | − | − | − | − |
| Ramos | Burkitt’s lymphoma | − | − | − | − | − | − |
| UOCB-1 | t(17;19) Pro-B-ALL | − | − | − | − | − | − |
| Jurkat | T-ALL | − | + | − | − | + | − |
| BM 1 | t(1;19) pre-B-ALL | ++ | + | ± | ++ | − | − |
| BM 2 | t(1;19) pre-B-ALL | + | + | ++ | ++ | + | + |
| BM 3 | t(1;19) pre-B-ALL | ++ | + | ± | + | − | + |
| BM 4 | t(1;19) pre-B-ALL | ++ | + | ++ | ++ | − | − |
| BM 5 | t(1;19) pre-B-ALL | ++ | + | ++ | ++ | ++ | − |
| BM 6 | Non-t(1;19) pre-B-ALL | − | − | ± | ± | − | + |
| BM 7 | Non-t(1;19) pre-B-ALL | ± | ± | ± | + | − | + |
| BM 8 | Non-t(1;19) pre-B-ALL | ± | − | ± | − | − | − |
| BM 9 | Non-t(1;19) pre-B-ALL | ± | − | ± | ± | − | − |
| BM 10 | Non-t(1;19) pre-B-ALL | ± | − | ± | − | − | + |
| BM 11 | t(9;22) CML | − | − | ± | − | − | − |
| BM 12 | t(9,22) CML | − | − | ± | − | − | − |
| BM 13 | t(12;21) pro-B-ALL | − | − | ± | − | − | − |
| BM 14 | t(12;21) pro-B-ALL | − | − | ± | − | − | − |
| BM 15 | Hyperdiploid | − | − | ± | ± | − | + |
| BM 16 | Normal cytogenetics | − | − | ± | − | − | − |
Gene expression was detected in leukemic cell lines by Northern blot analysis of poly(A)+ RNa and in patient bone marrow (BM) samples by RT-PCR analysis. Low levels of expression detectable by PCR but not by Northern or RNAse protection are indicated by ±. High levels of expression detected by PCR are indicated by + (10- to 20-fold above background) or ++ (20- to 100-fold above background).