Table 1.
Summary of genetic polymorphisms in the human CXCR1 and CXCR2 genes
| Polymorphisms |
Frequencies A1 |
P values for statistical tests (when <0.01) |
dbSNP ID | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | CNG ID | Position | Location | A1 | A2 | CTR | SP | RP | CTR vs. SP vs. RP | RP vs. NP | |
| CXCR1 | 305 | −2668 | Promoter | G | A | 0.95 | 0.95 | 0.95 | — | — | rs2671222 |
| 144 | −2423 | Promoter | G | A | 0.98 | 0.98 | 0.99 | — | — | rs17838611 | |
| 219 | −2329 | Promoter | C | T | 0.96 | 0.94 | 1.00 | 0.0008 | 0.0003 | rs16858841 | |
| 258 | −1566 | Intron | C | G | 0.94 | 0.95 | 0.95 | — | — | rs3138060 | |
| 200 | −143 | Intron | C | T | 0.96 | 0.94 | 1.00 | 0.0008 | 0.0003 | rs16858816 | |
| 300 | 92 | Exon (Met/Arg) | T | G | 0.96 | 0.94 | 1.00 | 0.001 | 0.0003 | rs16858811 | |
| 142 | 1003 | Exon (Arg/Cys) | C | T | 0.96 | 0.94 | 1.00 | 0.001 | 0.0002 | rs16858808 | |
| CXCR2 | 7222388 | −9203 | Promoter | A | G | 0.57 | 0.59 | 0.55 | — | — | rs3890158 |
| 7222389 | −9191 | Promoter | — | T | 0.57 | 0.59 | 0.56 | — | — | ss69355493 | |
| 7222390 | −9185 | Promoter | T | G | 0.96 | 0.93 | 1.00 | 0.0004 | 0.0003 | rs3890157 | |
| 7222391 | −9179 | Promoter | T | — | 0.52 | 0.59 | 0.57 | — | — | ss69355494 | |
| 7222394 | −8909 | Promoter | T | C | 0.52 | 0.52 | 0.54 | — | — | rs4674258 | |
| 7222386 | −8490 | Exon (5′-UTR) | A | G | 0.57 | 0.59 | 0.55 | — | — | rs4674259 | |
| 7222368 | −270 | Intron | G | A | 0.53 | 0.54 | 0.54 | — | — | ss69355495 | |
| 1913 | 768 | Exon (Val/Val) | C | T | 0.95 | 0.93 | 0.99 | 0.0015 | 0.0006 | rs11574750 | |
| 1425 | 786 | Exon (Leu/Leu) | C | T | 0.52 | 0.51 | 0.51 | — | — | rs2230054 | |
| 1271 | 936 | Exon (Leu/Leu) | C | T | 0.99 | 0.99 | 0.99 | — | — | ss69355496 | |
| 2464184 | 1209 | Exon (3′-UTR) | C | T | 0.57 | 0.58 | 0.51 | — | — | rs1126579 | |
| 7222360 | 1420 | Exon (3′-UTR) | A | G | 0.96 | 0.94 | 1.00 | 0.0004 | 0.0002 | rs13306441 | |
| 7222363 | 1437 | Exon (3′-UTR) | C | T | 0.01 | 0.01 | 0.01 | — | — | ss69355497 | |
| 2464185 | 1441 | Exon (3′-UTR) | G | A | 0.53 | 0.53 | 0.54 | — | — | rs1126580 | |
The position of each SNP was counted on the reference sequence (NT_005403.10) from the first nucleotide of the initiation codon as +1. A1 represents the nucleotide identical to that of the reference sequence. Single Nucleotide Polymorphism Database (dbSNP) IDs are also given for those that are already reported and registered on dpSNP (www.ncbi.nlm.nih.gov/SNP). P values for comparisons of the allele frequencies in the specified series are shown when <0.05. For these comparisons, adjustment for multiple testing (see Methods) gave P <0.01 in all instances except for the CTR vs. SP vs. RP comparison of SNP_7222390 in CXCR2 (P = 0.02). CNG, Centre National de Génotypage.