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. Author manuscript; available in PMC: 2008 Feb 23.
Published in final edited form as: Neuroscience. 2006 Dec 11;144(4):1436–1446. doi: 10.1016/j.neuroscience.2006.11.002

Table 1.

Experimental Design

Habituation Day Baseline Day Morphine Treatment Days 1–3 Test Day
Repeat Morphine
 S.C. Injection ----- Vehicle Morphine 5.6 mg/kg Morphine 5.6 mg/kg
 IC/ICV Injection Mock Vehicle ----- MNXa
 Operant Testing 30 min 30 min ----- 30 min
Single Morphine
 S.C. Injection ------ Vehicle Vehicle Morphine 5.6 mg/kg
 IC/ICV Injection Mock Vehicle ------ MNXa
 Operant Testing 30 min 30 min ------ 30 min
Morphine Naive
 S.C. Injection ------ Vehicle Vehicle Vehicle
 IC Injection Mock Vehicle ------ MNXb
 Operant Testing 30 min 30 min ------ 30 min
a

At one of 3 or more doses ranging from 16 to 2000 ng

b

At a single dose (highest dose tested in a given brain region)