. 2005 Dec 8;571(Pt 1):121–130. doi: 10.1113/jphysiol.2005.098558

Table 3.

Haplotype analysis based on positions 16 and 27 of the β₂-adrenergic receptor gene

Position 16	GlyGly				ArgGly			ArgArg

Position 27	GluGlu	GlnGlu	GlnGln	P-ANOVA	GlnGln	GlnGlu	P-ANOVA	GlnGln
Probable haplotype	2/2	2/6	6/6		4/6	2/4		4/4
n	12	12	7		8	9		16
Rest
MAP (mmHg)	98 ± 1.5	96 ± 1.6	103 ± 3.2	NS	106 ± 1.3	100 ± 2.9	NS	92 ± 1.4
Q̇ (l min⁻¹)	5.5 ± 1.2	7.7 ± 0.4	7.0 ± 0.4	< 0.001	6.1 ± 0.3	6.0 ± 0.3	NS	5.7 ± 0.2
HR (beats min⁻¹)	79 ± 1.4	79 ± 2.5	81 ± 2.7	NS	78 ± 2.5	79 ± 2.7	NS	86 ± 1.7
SV (ml beat⁻¹)	71 ± 3.1	103 ± 7.8	89 ± 4.9	< 0.001	81 ± 5.5	79 ± 4.6	NS	68 ± 2.9
SVR (dynes s cm⁻⁵)	1470 ± 50	1119 ± 70	1245 ± 86	0.001	1437 ± 64	1400 ± 77	NS	1333 ± 39
Light exercise
MAP (mmHg)	111 ± 1.9	110 ± 2.0	119 ± 4.4	NS	117 ± 1.9	112 ± 3.7	NS	102 ± 1.9
Q̇ (l min⁻¹)	10.4 ± 0.3	12.0 ± 0.5	11.8 ± 0.5	0.014	11.2 ± 0.4	10.7 ± 0.3	NS	9.8 ± 0.3
HR (beats min⁻¹)	126 ± 1.1	132 ± 2.6	126 ± 1.9	NS	119 ± 3.1	130 ± 3.2	0.02	130 ± 2.1
SV (ml beat⁻¹)	82 ± 2.1	94 ± 5.6	94 ± 4.9	NS	96 ± 5.1	84 ± 3.7	NS	77 ± 3.3
SVR (dynes s cm⁻⁵)	861 ± 17	762 ± 26	821 ± 37	0.013	870 ± 38	863 ± 42	NS	867 ± 25
Heavy exercise
MAP (mmHg)	115 ± 3.7	116 ± 25	127 ± 4.2	NS	129 ± 2.0	123 ± 3.8	NS	113 ± 2.3
Q̇ (l min⁻¹)	14 ± 0.5	17 ± 0.9	16 ± 0.8	0.022	16 ± 0.7	15 ± 0.5	NS	13 ± 0.5
HR (beats min⁻¹)	173 ± 1.6	181 ± 2.4	177 ± 2.2	0.024	173 ± 2.8	177 ± 2.0	NS	180 ± 1.7
SV (ml beat⁻¹)	80 ± 2.5	94 ± 6.0	91 ± 5.0	NS	93 ± 4.8	85 ± 3.4	NS	75 ± 2.7
SVR (dynes s cm⁻⁵)	696 ± 17	616 ± 26	664 ± 35	NS	677 ± 30	677 ± 32	NS	694 ± 17

Values are means ±s.e.m. 2 = ACGGCCCCGGGCC, 4 = GCACCTTTACGCC, 6 = GCGCCTTTGCACA, at nucleotides −1023, −709, −654, −468, −406, −367, −47, −20, 46, 79, 252, 491, and 523, respectively (Drysdale et al. 2000).