Table 3. MULTIVARIATE MODEL OF RISK FACTORS FOR CV MORTALITY IN MALES.

RISK PHENO-/GENOTYPE	MODEL 1 CLINICAL VARIABELES	P	MODEL 2 CLINICAL AND GENETIC VARIABLES	P
GYS1 XbaI (T)			1.9 [1.2–2.9]	3.5e−3 *
T2D	2.4 [1.6–3.7]	3.0e−5	2.5 [1.7–3.8]	1.2e−5
Fasting serum insulin	1.0 [1.0–1.0]	3.5e−2
Earlier CV events	1.9 [1.4–2.7]	2.1e−4	1.7 [1.2–2.5]	6.0e−3
Low physical activity	1.9 [1.3–2.8]	1.7e−3	1.9[1.2–2.9]	3.1e−3
Smoking	1.6 [1.0–2.3]	3.4e−2	1.5 [1.0–2.3]	3.2e−2
P-value (model, Wald test)		3.9e−14		7.0e−11

Multivariate Cox regression analysis using stepwise forward inclusion with robust variance estimates. Adjusted for age, sex and family correlations. * P_c = 0.018