Table 4. MULTIVARIATE MODEL OF RISK FACTORS FOR CV MORTALITY IN FEMALES.

RISK PHENO-/GENOTYPE	MODEL 1 CLINICAL VARIABELES	P	MODEL 2 CLINICAL AND GENETIC VARIABLES	P
APOE (E3E4/E4E4 and –219 TT)			2.9 [1.9–4.4]	2.6e−6 *
T2D	1.7 [1.0–2.9]	3.9e−2
Fasting plasma glucose	1.1 [1.1–1.2]	1.3e−5	1.2 [1.1–1.2]	2.3e−10
BMI			1.0 [1.0–1.1]	2.2e−2
Hypertension	1.6 [1.1–2.4]	2.9e−2	1.9 [1.2–3.1]	7.3e−3
Earlier CV events	1.6 [1.1–2.3]	1.2e−2	1.9 [1.3–2.8]	5.9e−4
Low physical activity	2.1 [1.4–3.1]	2.5e−4	1.9 [1.2–2.8]	4.9e−3
P-value (model, Wald test)		5.4e−14		<1.0e−10

Multivariate Cox regression analysis using stepwise forward inclusion with robust variance estimates. Adjusted for age, sex and family correlations. * P_c = 7.8e⁻⁶