Figure 4.
Simplified scheme for generating different sense organ types. Proneural genes in the achaete-scute Complex (AS-C) activate cut, which promotes es organ differentiation. cut may also be expressed early in chordotonal organ lineages due to some expression of AS-C genes, but cut activation is countered by expression of the proneural gene atonal to allow undifferentiated SOPs to give rise to CHO fates. It is not clear whether cut activation is mediated directly through AS-C genes or indirectly by genes downstream of AS-C to specify es organs. This caveat does not affect CHO lineage specification as atonal must still inhibit cut in these COPs.