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. 2006 Jan 19;571(Pt 3):695–701. doi: 10.1113/jphysiol.2005.102939

Figure 1. Neonatal PolyIC attenuates febrile response to adult PolyIC.

Figure 1

A, body temperature responses to an adult PolyIC challenge in animals that had been treated neonatally with either saline or PolyIC. Arrow indicates time of injection. B, animals that had been treated neonatally with PolyIC display significantly attenuated febrile responses to an adult PolyIC challenge compared to animals that had received saline neonatally (fever index; n = 7/group, P < 0.05). C, body temperature responses to an adult PolyIC challenge in animals that had received either PolyIC or saline 2 months earlier. D, there is no alteration in the adult febrile response to PolyIC when the first challenge occurs outside the neonatal period (fever index; n = 7/group, P > 0.05).