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. 2006 Jan 19;571(Pt 3):695–701. doi: 10.1113/jphysiol.2005.102939

Figure 3. Lack of programming by heterotypic immune stimuli.

Figure 3

A and D, animals that had been treated neonatally with LPS display similar corticosterone responses to an adult PolyIC challenge when compared to animals that had received saline neonatally (panel A, n = 6/group, P > 0.05). Similarly, animals that had received PolyIC neonatally displayed similar corticosterone responses to an adult LPS challenge when compared to animals that had received saline neonatally (panel D, n = 6/group, P > 0.05). B and E, body temperature responses to an adult immune challenge in animals that had been treated neonatally with PolyIC, LPS or saline. Animals that had been treated neonatally with LPS display similar febrile responses to an adult PolyIC challenge when compared to animals that had received saline neonatally (fever index; panel C, n = 7/group, P > 0.05). Similarly, animals that had received PolyIC neonatally displayed similar febrile responses to an adult LPS challenge when compared to animals that had received saline neonatally (fever index; panel F, n = 7/group, P > 0.05).