Table 2.
Brachial artery responses
| Young | Older | |||
|---|---|---|---|---|
| Parameter | Placebo | Allopurinol | Placebo | Allopurinol |
| Baseline D (mm) | 3.99 ± 0.19 | 3.97 ± 0.18 | 4.28 ± 0.22 | 4.34 ± 0.21 |
| Post-occlusion D (mm) | 3.90 ± 0.19 | 3.92 ± 0.20 | 4.25 ± 0.23 | 4.25 ± 0.23 |
| Baseline MBV (cm × s−1) | 5.0 ± 0.6 | 5.3 ± 0.5 | 4.5 ± 0.5 | 4.6 ± 0.4 |
| Peak MBV (cm × s−1) | 42.0 ± 3.7 | 42.3 ± 3.9 | 36.2 ± 2.5 | 33.4 ± 4.1 |
| SSbase (dyne × cm−2) | 3.6 ± 0.3 | 3.8 ± 0.2 | 2.9 ± 0.2 | 2.9 ± 0.3* |
| SSpeak (dyne × cm−2) | 31.9 ± 3.5 | 33.0 ± 3.5 | 22.5 ± 2.0* | 22.0 ± 1.9* |
| FMD (Δmm) | 0.29 ± 0.02 | 0.30 ± 0.03 | 0.14 ± 0.01* | 0.12 ± 0.02* |
| nFMD (Δmm/dyne × cm−2) × 103 | 9.8 ± 0.9 | 9.4 ± 1.4 | 5.9 ± 0.7* | 5.5 ± 1.4* |
| EID (Δ%) | 23.8 ± 3.6 | 21.9 ± 2.9 | 20.5 ± 2.7 | 21.2 ± 2.2 |
Data are mean ± s.e.m. D, diameter; MBV, mean blood velocity; FMD, flow-mediated dilatation; SSbase, baseline shear stress; SSpeak, peak shear stress; EID, endothelium-independent dilatation; nFMD = normalized FMD
*
P < 0.05 versus young.