Table 2.

Phenotypes of mice deficient in apoptotic cell uptake

Molecule	Phenotype of knockout mouse
C1q/C4	Systemic autoimmunity with autoantibodies and glomerulonephritis Increased numbers of apoptotic cells in glomeruli (C1q only) Delayed clearance of apoptotic cells from the peritoneal cavity
IgM	Autoimmunity to nuclear Ags; renal IgG and complement deposition
Mer/Tyro3/Axl & Mer (single KO)	Autoimmunity to nuclear Ags; renal IgG and complement deposition Defect in clearance of apoptotic cells in the thymus and spleen
MFG-E8	Glomerulonephritis, Splenomegaly, Autoantibodies, Numerous germinal centers with increased apoptotic B cells
PSR (Phosphaditylserine Receptor)	Abnormal development and neonatal lethality Accumulation of apoptotic cells in brain and lungs
CYP1B1	Proliferative immune-mediated glomerulonephritis; Autoantibodies; Histiocytic sarcomas; Defective cellular phagocytosis by peritoneal macrophages
DNaseI	Autoimmunity to chromatin; renal IgG and complement deposition Glomerulonephritis