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The ETRB antagonist BQ788 induces morphological changes in cultured melanoma cells. Cells were cultured for 4 days with 100 μM BQ788 (A and C) or with vehicle (B and D). The cell lines were melanoma line SK-MEL 28 (A and B) and melanoma line SK-MEL 5 (C and D). Note the different shape of the drug-treated melanoma cells and their accumulation of black pigment. Pictures were taken with bright-field optics at ×40 magnification.
