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. 1999 Sep 28;96(20):11525–11530. doi: 10.1073/pnas.96.20.11525

Figure 1.

Figure 1

Regulation of TGFβRII expression by the cholesterol metabolic pathway. Embryonic chicken atrial cells were cultured in media with either FCS or LPDS and treated with various HMGCoA reductase inhibitors each at 10 μM for 16 h. Lane 1, FCS; lane 2, LPDS; lane 3, LPDS plus pravastatin (Pra); lane 4, LPDS plus atorvastatin (Ato); lane 5, LPDS plus simvastatin (Sim). Thirty micrograms of crude cell extract were subjected to SDS/PAGE followed by immunoblotting with a TGFβRII antibody. Data are typical of four similar experiments.