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Coordinate regulation of TGFβRII and TGFβ1 promoter activity by control of the cholesterol metabolic pathway. Cells were transfected with either pTGFβRII-500/36-Lux (■) or phTGFβ5-Lux (□) plus pCMVβgal. After recovery, cells were incubated for 16 h in media with either FCS, LPDS, or LPDS plus simvastatin (20 μM). Luciferase activity was normalized to β-galactosidase activity. Data are plotted as the mean ± SEM of three independent experiments.
