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. 1999 Sep 28;96(20):11525–11530. doi: 10.1073/pnas.96.20.11525

Figure 5.

Figure 5

Regulation of TGFβ signaling by control of the cholesterol metabolic pathway. Embryonic chicken atrial cells were transfected with p3TP-Lux plus pCMVβgal. After recovery, cells were incubated for 16 h in media supplemented with either (A) FCS, LPDS, or LPDS plus various concentrations of simvastatin (0–10 μM); (B) LPDS and either: no additions; 10 μM simvastatin; 50 μM TMD; 10 μM FTI-277; 10 μM GGTI-298; 10 μM simvastatin plus 10 μM FPP; 10 μM simvastatin plus 10 μM GGPP. Luciferase activity was normalized to β-galactosidase activity. Values are the mean ± SEM of four independent experiments.