Figure 5.

CRH-BP-deficient mice exhibit increased anxiogenic-like behavior. (a) Elevated plus maze testing demonstrates that male −/− mice spend significantly less time in the open arms compared with +/+ mice. Percent of time spent in the open arms, ∗, P = 0.05. Percent of entries into the open arms, ∗∗, P = 0.02 (n = 50 wild-type male mice, 48 deficient male mice). (b) The defensive withdrawal test demonstrates that male −/− mice exit the small dark chamber significantly fewer times than the +/+ controls, ∗, P = 0.02. The latency period before first exit is longer for −/− mice than for +/+ controls, P = 0.2 (n = 5 wild-type male mice, 10 deficient male mice). (c) Zone monitoring in the open field demonstrates that the −/− mice spend less time in the inner zone of the open field as compared with +/+ mice. Percent of time spent in the inner zone, P = 0.06. Percent of grids crossed in the inner zone, P = 0.08 (n = 26 wild-type mice, 26 deficient mice).