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. 2007 Feb 9;8(3):265–270. doi: 10.1038/sj.embor.7400891

Figure 1.

Figure 1

Induction of PKR tyrosine phosphorylation by interferons. The indicated cells were treated with IFN-γ for the indicated time periods. (A,B) Protein extracts were subjected to PKR immunoprecipitation (IP) followed by immunoblotting with the phosphotyrosine 4G10 monoclonal antibody (panel a). The total PKR protein levels are shown in panel b. The ratio of phosphorylated to total PKR for each lane is indicated. IFN, interferon; PKR, dsRNA-dependent protein kinase; TC-PTP, T-cell protein tyrosine phosphatase.