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Untransformed pharmacokinetic parameters after administration of OROS® hydromorphone 8, 16, 32, and 64 mg (n = 31)
| Parameter | 8 mg | 16 mg | 32 mg | 64 mg |
| Cmax (ng/mL) | ||||
| Mean | 0.929 | 1.69 | 3.25 | 6.61 |
| SD | 1.01 | 0.78 | 1.37 | 1.75 |
| Tmax (hour) | ||||
| Median | 12.0 | 16.0 | 16.0 | 16.0 |
| Range | 4.0–30.0 | 6.0–30.0 | 4.0–24.0 | 6.0–30.0 |
| AUC0–48 (ng·hr/mL) | ||||
| Mean | 18.1 | 36.5 | 72.2 | 156 |
| SD | 5.8 | 11.3 | 24.3 | 30.6 |
| AUC0–∞ (ng·hr/mL) | ||||
| Mean | 19.5 | 40.8 | 80.3 | 178.7 |
| SD | 5.9 | 13.7 | 29.6 | 35.2 |
| t1/2 (hour) | ||||
| Mean | 10.6 | 10.3 | 11.0 | 10.9 |
| SD | 4.3 | 2.4 | 3.2 | 3.8 |
