Table 3.
McDonald-Kreitman test on the Tep genes
| Fixed differences |
Polymorphism, melanogaster |
Polymorphism, simulans |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Region | Silent | Replace | Silent | Replace | p a | Silent | Replace | p a |
| TepI | Coding (bait) | 2 | 18 | 0 | 0 | - | |||
| Coding (nonbait) | 70 | 153 | 10 | 7 | 0.03 | ||||
| All coding | 72 | 171 | 10 | 7 | 0.03 | ||||
| Intron + coding | 129 | 171 | 18 | 7 | 0.006 | ||||
| TepII | Coding (bait exon 5) | 3 | 3 | 0 | 0 | n.s. | 2 | 2 | n.s. |
| Coding (bait exon 6) | 0 | 2 | 2 | 0 | n.s. | 1 | 1 | n.s. | |
| Coding (bait exon 7) | 3 | 9 | 1 | 0 | n.s. | 0 | 4 | n.s. | |
| Coding (bait exon 8) | 2 | 5 | 0 | 0 | n.s. | 0 | 2 | n.s. | |
| Coding (bait exon 9) | 9 | 26 | 1 | 3 | n.s. | 0 | 6 | n.s. | |
| Coding (bait all exons) | 17 | 45 | 4 | 3 | n.s. | 3 | 15 | n.s. | |
| Coding (nonbait) | 105 | 61 | 48 | 26 | n.s. | 57 | 37 | n.s. | |
| All coding | 122 | 106 | 52 | 29 | n.s. | 60 | 52 | n.s. | |
| Intron + coding | 265 | 106 | 102 | 29 | n.s. | 129 | 52 | n.s. | |
| TepIV | Coding (bait) | 4 | 6 | 1 | 1 | n.s. | |||
| Coding (nonbait) | 59 | 29 | 14 | 14 | n.s. | ||||
| All coding | 63 | 35 | 15 | 15 | n.s. | ||||
| Intron + coding | 76 | 35 | 20 | 15 | n.s. | ||||
a
Two-tailed Fisher exact test. Dataset includes a single additional allele from the genome sequences of D. simulans and D. melanogaster.