Table 1.
Effects of rat chromosome 10 congenic strains on blood pressure, body weight, heart weight, and relative heart weight.
| Blood Pressure (mmHg)
|
Body Weight (gm)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Congenic Strain | S | Congenic | **Effect | t-test | S | Congenic | **Effect | t-test |
| S.LEWx12 | 242 [3.70] | 217 [4.28] | −25 (5.66) | <0.0001 | 303 [2.86] | 303 [1.14] | 0 (3.08) | 0.910 |
| S.LEWx12x1 | 218 [3.10] | 183 [2.07] | −35 (4.27) | <0.0001 | 311 [2.11] | 299 [5.81] | −12 (5.81) | 0.110 |
| S.LEWx12x2 | 215 [3.72] | 184 [3.05] | −31 (4.76) | <0.0001 | 297 [3.75] | 299 [3.42] | +2 (5.07) | 0.619 |
| S.LEWx12x3 | 191 [1.58] | 186 [3.21] | −5 (3.71) | 0.444 | 320 [1.52] | 315 [2.77] | −5 (3.59) | 0.314 |
| S.LEWx12x4*† | 190 [1.61] | 192 [2.45] | +2 (2.81) | 0.525 | 314 [2.00] | 306 [2.61] | −8 (3.23) | 0.012 |
| S.LEWx12x6† | 189 [2.92] | 192 [3.89] | +3 (4.45) | 0.842 | 307 [3.23] | 291 [3.33] | −16 (4.49) | 0.002 |
| S.LEWx12x2x1 | 196 [2.53] | 191 [4.07] | −5 (4.79) | 0.315 | 318 [2.25] | 317 [2.48] | −1 (3.35) | 0.697 |
| S.LEWx12x2x3* | 206 [2.23] | 189 [2.28] | −17 (3.20) | <0.0001 | 303 [1.92] | 305 [1.96] | +2 (2.75) | 0.449 |
| Heart Weight (gm)
|
Relative Heart Weight
|
|||||||
| Congenic Strain | S | Congenic | **Effect | t-test | S | Congenic | **Effect | t-test |
| S.LEWx12 | 1.31 [0.015] | 1.22 [0.009] | −0.09 (0.018) | <0.0001 | 4.26 [0.067] | 4.02 [0.035] | −0.24 (0.075) | 0.003 |
| S.LEWx12x1 | 1.23 [0.018] | 1.10 [0.019] | −0.13 (0.028) | <0.0001 | 3.96 [0.053] | 3.68 [0.032] | −0.27 (0.058) | <0.0001 |
| S.LEWx12x2 | 1.26 [0.038] | 1.16 [0.015] | −0.10 (0.039) | 0.023 | 4.26 [0.163] | 3.89 [0.039] | −0.36 (0.156) | 0.025 |
| S.LEWx12x3 | 1.25 [0.010] | 1.21 [0.010] | −0.04 (0.015) | 0.059 | 3.90 [0.024] | 3.86 [0.033] | −0.04 (0.054) | 0.713 |
| S.LEWx12x4*† | 1.21 [0.007] | 1.21 [0.011] | 0 (0.004) | 0..720 | 3.88 [0.029] | 3.98 [0.059] | +0.10 (0.061) | 0.145 |
| S.LEWx12x6† | 1.18 [0.013] | 1.18 [0.011] | 0 (0.016) | 0.751 | 3.85 [0.048] | 4.09 [0.068] | +0.24 (0.083) | 0.222 |
| S.LEWx12x2x1 | 1.26 [0.047] | 1.26 [0.016] | 0 (0.022) | 0.728 | 3.95 [0.048] | 3.99 [0.048] | +0.04 (0.068) | 0.564 |
| S.LEWx12x2x3* | 1.25 [0.013] | 1.21 [0.007] | −0.04 (0.016) | 0.014 | 4.15 [0.050] | 3.99 [0.024] | −0.16 (0.059) | 0.006 |
The values given here were the averages of experiments done on separate days. Two separate experiments for S.LEWx12x4 and 3 separate experiments for S.LEWx12x2x3.
Effect = Congenic value − S value. Negative values indicate a decrease in the congenic effect compared to the S rat, whereas positive values indicate an increase in the congenic effect compared to the S rat.
Heart weight values given were corrected for body weight using the regression between heart weight and body weight. [Standard error of the mean]. (Standard error of the mean difference). Number of rats in each group ranged from 20 to 23 except for the following comparisons: S.LEWx12x4 versus S (32 versus 44 rats), and S.LEWx12x2x3 versus S (30 versus 30 rats). Only male rats were used.