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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: J Pediatr. 2007 Jan;150(1):83–88. doi: 10.1016/j.jpeds.2006.10.048

Table I.

DXA Statistical Analysis (NF1 versus Controls)*

Variable NF1 Individuals Healthy Controls p-value
Adjusted Mean Adjusted SE N Adjusted Mean Adjusted SE N
Hip
 Bone Area (cm2)
 BMC (gm)
 aBMD (gm/cm2)
23.11
17.51
0.697
0.44
0.54
0.011
81
81
81
25.77
21.48
0.779
0.29
0.36
0.007
290
290
290
p<0.0001
p<0.0001
p<0.0001
Femoral Neck
 Bone Area (cm2)
 BMC (gm)
 aBMD (gm/cm2)
 BMAD (gm/cm3)
4.21
2.81
0.646
0.154
0.04
0.06
0.010
0.003
81
81
81
81
4.24
3.16
0.720
0.17
0.03
0.04
0.007
0.002
290
290
290
290
p=0.6305
p<0.0001
p<0.0001
p<0.0001
Lumbar Spine
 Bone Area (cm2)
 BMC (gm)
 aBMD (gm/cm2)
 BMAD (gm/cm3)
43.8
31.5
0.674
0.101
0.54
0.85
0.011
0.0015
78
78
78
78
44.9
34.3
0.711
0.105
0.35
0.56
0.007
0.001
292
292
292
292
p=0.0629
p<0.0034
p<0.0025
p=0.0161
Whole Body Subtotal
 Bone Area (cm2)
 BMC (gm)
 aBMD (gm/cm2)
1127
909
0.731
16
21
0.007
75
75
75
1201
1021
0.777
10
13
0.004
292
292
292
p<0.0001
p<0.0001
p<0.0001
*

Comparison of the bone variables from DXA imaging between NF1 individuals and controls was adjusted for gender, Tanner stage, weight, height, and age using analysis-of-covariance with a fixed set of covariates. P-values are not adjusted for multiple comparisons. (DXA=dual energy x-ray absorptiometry; aBMD= areal bone mineral density; BMAD= bone mineral apparent density; BMC=bone mineral content; SE=standard error).