5.
Inhibitors of taurine accumulation in hippocampal neuron cultures. Cells were exposed to tracer quantities of [3H]-taurine in isoosmotic PBS containing 1 μM unlabeled taurine (control) or to the same specific activity of taurine plus 1 mM of the indicated compound for 20 min before sampling to determine radioactive taurine accumulation. Results are expressed as the radioactivity cleared from a volume of extracellular fluid in order to compare inhibition by added unlabeled taurine with that of other compounds. Data points are the mean ± SEM of 5-6 independent measurements. All values from cultures with added compounds are significantly different from the control accumulation rate.