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. Author manuscript; available in PMC: 2007 Mar 2.
Published in final edited form as: Biochem Pharmacol. 2006 Oct 13;73(3):331–340. doi: 10.1016/j.bcp.2006.10.005

Figure 5.

Figure 5

Dose response curves for Complex I inhibition of K562 Cells by the five strongest inhibitors confirmed by Table I. Dose response curves are based upon the change in rate of oxygen consumption when increasing concentrations (range=1nM to 1mM) of inhibitors of Complex I are added, after 1x107 cells have been permeabilized with digitonin and energized with Complex I substrates. The IC50's obtained by the dose -response curves for each compound were obtained by non-linear regression analysis, one-site competition, using GraphPad Prizm. n=2–4 separate experiments for each concentration.