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Free energy parameters for internal loops.
| Parameter | Explanation | Values |
| ΔG-length-I(n) | Destabilizing energy of internal loop of size n (n = 4, 5, 6,...) | 1.7, 1.8, 2.0,... |
| ΔG-length-B(n) | Destabilizing energy of bulge of size n (n = 1, 2, 3,...) | 3.8, 2.8, 3.2,... |
| ΔG-Internal-n (si, sj, si+1, sj-1) | Terminal mismatch free energy of closing base pair (si·sj) and neighbouring free bases si+1 and sj-1 | -1.1, -0.7, -0.4, 0.0 and 0.7 |
| ΔG-Asymmetry(l1, l2) | Penalty for asymmetric internal loops |
