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. Author manuscript; available in PMC: 2007 Mar 4.
Published in final edited form as: Neurology. 2004 Sep 14;63(5):805–811. doi: 10.1212/01.wnl.0000139870.14385.3c

Figure 2.

Figure 2

Locations and coding sequence conservation of the dementia with Lewy bodies–associated SNCB alterations. (A) Comparison of pathogenic SNCA mutation locations and putatively pathogenic SNCB alterations is shown. In the synuclein proteins, an 11-residue domain with a KTKEGV consensus repeat (shaded regions) has been proposed to exist and comprises the region to which all three known SNCA disease mutations localize. (B) Sequence comparison of the middle region of SNCB across rodent, human, and bovine species. The valine (V) at position 70 is boxed to indicate its location. As seen here, this valine residue is 100% conserved across a wide range of mammalian species, suggesting its potential functional importance. Genbank accession numbers are as follows: Q63754 (rat), AAK83238 (mouse), AAB30860 (human), and P33567 (bovine). (C) Sequence comparison of the carboxy-terminal region of SNCB across rodent, human, and bovine species. The proline (P) at position 123 is boxed to indicate its location. As shown here, the proline residue at position 123 is 100% conserved across a wide range of mammalian species, suggesting its potential functional importance. Accession numbers are as above.