Fig 1.

(a) Immunohistochemical demonstration of SLPI in nasal biopsies from patients suffering from Wegener's granulomatosis. Utilizing a goat anti-SLPI diluted 1/1000 and DAB as a chromogen, positive staining is seen in the serous cells. Magnification 1 : 1250. (b) Demonstration of SLPI-mRNA by in situ hybridization of nasal biopsies from patients with Wegener's granulomatosis. The specimens were hybridized using an equimolar cocktail of three 30-base-long anti-sense, digoxigenin-labelled oligonucleotides as probes. Positive staining is seen in the serous cells of the mucosa. Magnification 1 : 5000.