Table 2.
The replacement to silent mutation ratios of the heavy chains for the 15 anti-DNA Fabs. Figures in italics are those for which there are no silent mutations
| Antibody code | R/S ratio in CDR 1 and 2 | R/S ratio in CDR 1 | R/S ratio in CDR 2 | R/S ratio in the framework region | Transition mutation rate |
|---|---|---|---|---|---|
| R5C08 | 1·3 | 1·0 | 1·5 | 2·5 | 42·9 |
| R4C17 | 3·0 | 0·0 | 3·0 | 3 | 72·7 |
| R4C09 | 3·0 | 0·0 | 3·0 | 0·7 | 35·7 |
| R4C12 | 0·0 | 0·0 | 0·0 | 2·5 | 77·8 |
| R5C02 | 1·0 | 1·0 | 0·7 | 4·5 | 66·7 |
| P253 | 3·0 | 2·0 | 1·0 | 5 | 45·5 |
| R5C20 | 2·5 | 2·5 | 0·0 | 2 | 38·5 |
| R4C07 | 1·0 | 1·0 | 0·5 | 3·6 | 65·5 |
| P212 | 3·0 | 2·0 | 1·0 | 3 | 47·8 |
| R4C15 | 3·0 | 0·0 | 3·0 | 3 | 53·3 |
| R4C03 | 3·0 | 4·0 | 2·0 | 3 | 37·3 |
| R5C06 | 5·0 | 0·0 | 5·0 | 8 | 57·9 |
| R4C04 | 7·0 | 2·0 | 5·0 | 2·75 | 33·3 |
| R5C16 | 8·0 | 4·0 | 4·0 | 3·75 | 30·8 |
| R5C09 | 9·0 | 6·0 | 3·0 | 1·625 | 28·1 |
| Mean | 3·4 | 1·7* | 2·2 | 3·2 | 48·9 |
*
Probability value, P > 0·003 when compared with combined R/S ratio for CDR1 and 2; not significant when compared with the R/S ratio for CDR2.