Table 4.

A comparison of the mean replacement to silent ratios of the heavy chains paired with specific light chains. Antibodies using the different somatic variants of the A27/Jκ1 light chain are treated as two separate groups. As only two antibodies used the somatic variants of the B3/Jκ4 light chain, these they are treated together. Mean ± s.e.m.

	Number of antibodies	R/S ratio for heavy chain CDRs 1 and 2	R/S ratio for CDR1	R/S ratio for CDR2
A27 (1)	6	2·83 ± 0·27	1·33 ± 0·19	1·69 ± 0·12
A27 (2)	3	″ 5 ± 0·33	0·67 ± 0·19	4·33 ± 0·19
B3	2	2·97 ± 0*	0·53 ± 0*	2·88 ± 0*
A20	4	4·55 ± 0·37	3·50 ± 0·19	2·10 ± 0·15

^*The numbers of mutations in both heavy chains was identical. For an explanation of A27 (1) and A27 (2) see the legend to Table 3.