Table 1.

Amino acid sequences of peptides based on the CDRs of murine and human monoclonal anti-DNA, 16/6Id autoantibodies

mCDR1

T

G

Y

Y

M

Q

W

V

K

Q

S

P

E

K

S

L

E

W

I

G

hCDR1

G

Y

Y

W

S

W

I

R

Q

P

P

G

K

G

E

E

W

I

G

mCDR3

Y

Y

C

A

R

F

L

W

E

P

Y

A

M

D

Y

W

G

Q

G

S

hCDR3

Y

Y

C

A

R

G

L

L

R

G

G

W

N

D

V

D

Y

Y

G

M

D

V

Reversed mCDR1

G

I

W

E

L

S

K

E

P

S

Q

K

V

W

Q

M

Y

Y

G

T

Reversed mCDR3

S

G

Q

G

W

Y

D

M

A

Y

P

E

W

L

F

R

A

C

Y

Y

Peptides based on the CDR1 and CDR3 of the murine autoantibody were designated mCDR1 and mCDR3, respectively, and peptides based on the CDRs of the human autoantibody were designated hCDR1 and hCDR3.