Table 2.

Neopterin concentrations (nm; mean values ± s.e.m. of three experiments performed in triplicate) in supernatants of THP-1 stimulated with IFN-γ, lipopolysaccharide (LPS) at different concentrations and mixtures and treated with atorvastatin for 24 h

Treatment	Atorvastatin 0 µm	Atorvastatin 10 µm	Atorvastatin 100 µm
None	2·3 ± 0·1	2·3 ± 0·2	2·3 ± 0·2
IFN-γ 100 U/ml	4·8 ± 1·2*	4·3 ± 0·8	2·6 ± 0·2‡
LPS 1 µg/ml	3·9 ± 0·5*	4·0 ± 0·6	2·4 ± 0·1‡
LPS 10 µg/ml	3·2 ± 0·5*	3·4 ± 0·5	2·5 ± 0·4‡
IFN-γ + LPS 1 µg/ml	29·2 ± 7·2*	23·4 ± 6·2§	4·1 ± 1·5†
IFN-γ + LPS 10 µg/ml	22·1 ± 8·8*	19·9 ± 7·6	3·2 ± 0·7†

^*P < 0·001 (compared with unstimulated cells)

^†P < 0·001 and

^‡P < 0·01

^§P < 0·05 (compared with stimulated cells without atorvastatin).