Fig. 5.

Serum levels of soluble gp130 (a) and autoantibodies to IL-6 (b) in patients with systemic JIA (s-JIA) (open bar in panel a) and in healthy controls (CTRL) (hatched bar in panel a). Sgp130 levels were measured by ELISA as described in the method section. For the determination of antibodies to IL-6, a reference Ig preparation with high levels of autoantibodies to hIL-6 (IgG anti-IL-6), or sera from patients with s-JIA (n = 11) and from controls (n = 8) were incubated with ¹²⁵I-rIL-6 and then subjected to chromatography on Sephadex G-75 as described in the method section. Results are expressed as the ratio between bound and total added ¹²⁵I-rIL-6. Results are shown as means + SD, represented by the vertical bars.