Table 2.
Analysis of experimental and clinical data with respect to FcγRIIA and FcγRIIIA genotypes and alleles of the subjects
| FcγRIIA genotype or allele | FcγRIIIA genotype or allele | Combinations of FcγRIIA and FcγRIIIA alleles | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R/R 131 | R/H 131 | H/H 131 | R 131 | H 131 | V/V 158 | V/F 158 | F/F 158 | V 158 | F 158 | R 131 V 158 | R 131 F 158 | H 131 V 158 | H 131 F 158 | |
| Number of subjects | 9 | 10 | 3 | 19 | 13 | 2 | 3 | 17 | 5 | 20 | 4 | 17 | 4 | 12 |
| (% of total) | (41) | (45) | (14) | (86) | (59) | (9) | (14) | (77) | (23) | (91) | (18) | (77) | (18) | (55) |
| % phagocytosis by monocytes | ||||||||||||||
| Mean | 26·3 | 27·9 | 25·7 | 27·2 | 27·4 | 37·5 | 33·3 | 24·4 | 35·0 | 25·8 | 39·8 | 25·9 | 35·3 | 26·3 |
| SEM | 6·7 | 4·5 | 7·8 | 3·8 | 3·8 | 3·5 | 9·3 | 4·0 | 5·3 | 3·6 | 3·1 | 6·9 | 6·9 | 3·9 |
| % haemolysis by NK cells | ||||||||||||||
| Mean | 81·3 | 89·1 | 91·3 | 85·9 | 89·6 | 79·5 | 85·3 | 87·9 | 83·0 | 87·5 | 87·0 | 86·7 | 85·8 | 89·8 |
| SEM | 4·9 | 2·6 | 12·3 | 2·6 | 3·2 | 7·5 | 9·3 | 3·2 | 5·8 | 3·0 | 5·4 | 2·8 | 6·6 | 3·4 |
| Half life, t50% | ||||||||||||||
| Mean | 8·3 | 16·6 | 8·8 | 12·7 | 14·8 | 14·5 | 14·6 | 10·2 | 14·6 | 10·9 | 15·0 | 12·5 | 17·6 | 13·8 |
| SEM | 2·9 | 4·2 | 3·1 | 2·7 | 3·4 | 12·2 | 5·2 | 2·6 | 4·8 | 2·3 | 6·1 | 2·8 | 4·7 | 3·5 |