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. 2003 Apr;132(1):40–45. doi: 10.1046/j.1365-2249.2003.02103.x

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Fig. 2 — Effect of treatment with naltrexone on heroin-induced enhancement of IL-12 production. BALB/mice were untreated or treated with PBS (▪), heroin (□) or with naltrexone 15 min before heroin injection . PEC were harvested 20 min after the heroin administration and were stimulated with LPS/IFN-γ. The production of IL-12 was determined after 48 h by ELISA. Each bar represents the mean ± s.e. from three experiments. Value with asterisk represents statistically significant (P < 0·01) enhancement of IL-12 production in comparison with control untreated mice.

Inline graphic — Effect of treatment with naltrexone on heroin-induced enhancement of IL-12 production. BALB/mice were untreated or treated with PBS (▪), heroin (□) or with naltrexone 15 min before heroin injection . PEC were harvested 20 min after the heroin administration and were stimulated with LPS/IFN-γ. The production of IL-12 was determined after 48 h by ELISA. Each bar represents the mean ± s.e. from three experiments. Value with asterisk represents statistically significant (P < 0·01) enhancement of IL-12 production in comparison with control untreated mice.