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Enhanced NO production after heroin administration. BALB/c mice were untreated(
) or treated with PBS (▪) or heroin (□) and their PEC were harvested after 20 min. The cells were stimulated with LPS/IFN-γ and the presence of NO in the supernatants was detected after 48 h using a Griess reaction. Each bar represents the mean ± s.e. from three experiments. Values with asterisk represent NO production that was statistically different (P < 0·01) from untreated controls.
