Table 3.

Inhibitory effects of oral CII treatment on hind paw swelling in AA rats

	Paw swelling (ml)
group 20	day 20	day 24	day 28
Normal	0·15 ± 0·04	0·23 ± 0·06	0·32 ± 0·07
AA	0·53 ± 0·07**	0·77 ± 0·03**	0·94 ± 0·07**
CII
5 (µg/kg)	0·43 ± 0·09‡ (20·2)	0·56 ± 0·04‡ (27·6)	0·65 ± 0·06‡ (30·5)
50 (µg/kg)	0·37 ± 0·06‡ (30·9)	0·57 ± 0·06‡ (20·6)	0·41 ± 0·08‡ (34·5)
500 (µg/kg)	0·37 ± 0·05‡ (31·1)	0·49 ± 0·09‡ (35·8)	0·62 ± 0·06‡ (34·2)

Adjuvant arthritis (AA) was induced by a single intradermal injection of 100 µl of Complete Freund's Adjuvant into the left hind paw. Vehicle (0·01 M acetic acid) or different daily doses of bovine CII were fed for 7 days from day 13 after immunization. The right hind paw volume was measured with a water replacement plethsmometer at day 0, 20, 24 and 28 after immunization. Paw swelling (ml) was calculated by taking away the paw volume at day 0 from the relevant one at day 20, 24 and 28. Results are representative of two similar experiments and expressed as mean ± SD, n= 5.

^**P < 0·01 versus Normal group,

^‡P < 0·01 versus AA group. Numbers in parenthesis represent the percentage inhibition.