Fig. 1.

STAT 6 deficient (STAT6^–/–) mice exhibit a reduced CHS elicitation to PPD. STAT6^–/– mice (□ Olive-STAT6^–/–; ▪ PPD-STAT6^–/–) and wild type (WT) mice (▵ Olive-WT; ▴ PPD-WT) were contact sensitized for five days with 2·5% PPD, 2 days after the last immunization, and thereafter both mice were challenged. The maximal ear swelling was detected at 24 h for the wild type mice and at 48 h for the STAT6^–/– mice. The data presented are the mean values ± SD of five mice per group and are representative of five experiments. *P < 0·01, significant compared to the results obtained with WT mice