Table 4.
.Distribution of CDR3 length in IgM and IgG from young and aged humans
| CDR3 length in amino acids, no. of sequences (%) | |||||||
|---|---|---|---|---|---|---|---|
| No. of analysed sequences | < 3 | 4–8 | 9–13 | 14–18 | 19–23 | 24 < | |
| IgM naive | |||||||
| Young | 37 | 0 (0·0) | 1 (2·7) | 9 (24·3) | 19 (51·4) | 7 (18·9) | 1 (2·7) |
| Aged | 28 | 0 (0·0) | 1 (3·6) | 17 (60·7) | 6 (21·4) | 3 (10·7) | 1 (3·6) |
| IgM memory | |||||||
| Young | 59 | 0 (0·0) | 6 (10·2) | 35 (59·3) | 14 (23·7) | 4 (6·8) | 0 (0·0) |
| Aged | 38 | 0 (0·0) | 3 (7·9) | 21 (55·3) | 11 (28·9) | 3 (7·9) | 0 (0·0) |
| IgG | |||||||
| Young | 82 | 0 (0·0) | 5 (6·1) | 42 (51·2) | 31 (37·8) | 3 (3·7) | 1 (1·2) |
| Aged | 75 | 0 (0·0) | 2 (2·7) | 46 (61·3) | 22 (29·3) | 5 (6·7) | 0 (0·0) |
| Total | 319 | 0 (0·0) | 18 (5·6) | 170 (53·3) | 103 (32·3) | 25 (7·8) | 3 (1·0) |
| Adults B cells (%)a | 0·0 | 13·3 | 41·4 | 37·3 | 6·7 | 1.3 | |
a
These data were cited from healthy adult peripheral B cell analysis reported by Yamada et al. [18].