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. 2003 Jul;133(1):59–66. doi: 10.1046/j.1365-2249.2003.02185.x

Table 5.

.D and JH segment usage in IgM and IgG from young and aged humans

No. of sequences (%)
D segment IgM naive IgM memory IgG
New namea Old name Young Aged Young Aged Young Aged Total Control (%)
1–1 n.a.  0 (0·0)  0 (0·0)  1 (1·7)  0 (0·0)  0 (0·0)  1 (1·3)  2 (0·6)  0·6
2–2 DLR4  3 (8·1)  0 (0·0)  0 (0·0)  0 (0·0)  4 (4·7)  1 (1·3)  8 (2·4)  3·7
3–3 DXP4  2 (5·4)  2 (7·1)  0 (0·0)  0 (0·0)  3 (3·5)  3 (3·8)  10 (3·1)  4·8
4–4 DA4  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  1 (1·3)  1 (0·3)  0·3
5–5 DK4  0 (0·0)  0 (0·0)  1 (1·7)  1 (2·6)  1 (1·2)  0 (0·0)  3 (0·9)  1·2
6–6 DN4  0 (0·0)  0 (0·0)  0 (0·0)  1 (2·6)  1 (1·2)  1 (1·3)   3 (0·9)   1·3
1–7 DM1  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0·5
2–8 DLR1  0 (0·0)  0 (0·0)  0 (0·0)  1 (2·6)  0 (0·0)  2 (2·6)  3 (0·9)  0·8
3–9 DXP1  1 (2·7)  1 (3·6)  0 (0·0)  1 (2·6)  0 (0·0)  2 (2·6)  5 (1·5)  2·1
3–10 DXP′1  6 (16·2)  4 (14·3)  3 (5·1)  2 (5·1) 12 (14·0)  6 (7·7)  33 (10·1)  8·1
4–11 DA1  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0·3
5–12 DK1  3 (8·1)c  1 (3·6)  0 (0·0)  0 (0·0)  2 (2·3)  2 (2·6)  8 (2·4)  1·6
6–13 DN1  2 (5·4)c  1 (3·6)  1 (1·7)  1 (2·6)  1 (1·2)  3 (3·8)  9 (2·8)  3·5
1–14 DM2  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0·0
2–15 DLR2  4 (10·8)  2 (7·1)  1 (1·7)  4 (10·3)  4 (4·7)  2 (2·6)  17 (5·2)  2·4
3–16 n.a.  1 (2·7)  0 (0·0)  2 (3·4)c  1 (2·6)  3 (3·5)  3 (3·8)  10 (3·1)  1·0
4–17 n.a.  0 (0·0)  1 (3·6)  3 (5·1)  0 (0·0)  2 (2·3)  0 (0·0)  6 (1·8)  2·4
5–18 n.a.  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  1·2
6–19 n.a.  0 (0·0)  3 (10·7)  5 (8·5)  4 (10·3)  1 (1·2)  6 (7·7)  19 (5·8)  4·7
1–20 n.a.  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0·7
2–21 DLR3  0 (0·0)  0 (0·0)  1 (1·7)  0 (0·0)  1 (1·2)  2 (2·6)  4 (1·2)  1·2
3–22 D21/9  4 (10·8)  1 (3·6)  6 (10·2)  3 (7·7)  4 (4·7)  2 (2·6)  20 (6·1)  3·8
4–23 n.a.  1 (2·7)  0 (0·0)  0 (0·0)  0 (0·0)  6 (7·0)  6 (7·7)  13 (4·0)  1·1
5–24 n.a.  1 (2·7)  1 (3·6)  1 (1·7)  0 (0·0)  1 (1·2)  0 (0·0)  4 (1·2)  0·8
6–25 n.a.  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0 (0·0)  0·0
1–26 n.a.  0 (0·0)  0 (0·0)  6 (10·2)c  2 (5·1)  4 (4·7)  2 (2·6)  14 (4·3)  1·7
7–27 DHQ52  0 (0·0)  0 (0·0)  1 (1·7)  0 (0·0)  0 (0·0)  0 (0·0)  1 (0·3)  0·9
Not detectedb 10 (27·0) 11 (39·3) 28 (47·5) 18 (46·2) 36 (41·9) 33 (42·3) 136 (41·6)  49.5
Total 37 (100·0) 28 (100·0) 59 (100·0) 39 (100·0) 86 (100·0) 78 (100·0) 327 (100·0) 100.0
JH segment
 JH 1  0 (0·0)  1 (3·6)  0 (0·0)  0 (0·0)  2 (2·5)  0 (0·0)  3 (1·0)  1·0
 JH 2  2 (5·4)  2 (7·1)  0 (0·0)  0 (0·0)  2 (2·5)  1 (1·3)  7 (2·2)  0·0
 JH 3  5 (13·5)  7 (25·0) 10 (17·2)  4 (10·5) 11 (13·9)  8 (10·7)  45 (14·3)  9·1
 JH 4 15 (40·5) 13 (46·4) 35 (60·3) 22 (57·9) 42 (53·2)  38 (50·7) 165 (52·4)  52·5
 JH 5  5 (13·5)  0 (0·0)  3 (5·2)  8 (21·1)  9 (11·4)  17 (22·7)  42 (13·3)  15·2
 JH 6 10 (27·0)  5 (17·9) 10 (17·2)  4 (10·5) 13 (16·5)  11 (14·7)  53 (16·8)  22·2
 Total 37 (100·0) 28 (100·0) 58 (100·0) 38 (100·0) 79 (100·0)  75 (100·0) 315 (100·0) 100·0e
a

Names of the 27 human functional D segments are as in Corbett et al. [14]. The 27 D segments are aligned on the basis of their relative positions in the D locus. 1–1 is the most VH locus-proximal and 7–27 the most JH locus-proximal.

b

Not detected indicates sequences in which no D segment was able to be assigned in this study.

c

These data include sequences in which D–D fusion was detected. D–D fusion was treated as two identified D segments.

d

These data were cited from rearranged heavy chain sequence analysis reported by Corbett et al. [14].

e

These data were cited from healthy adult peripheral B cell analysis reported by Yamada et al. [18]. n.a.: Not available.