Table 1.
Clinical characteristics and basal cytokine release from colonic explants
| N-IC | CD− | IC | CD+ | UC+ | |
|---|---|---|---|---|---|
| n | 26 | 30 | 20 | 45 | 21 |
| Sex (M/F) | 12/14 | 16/14 | 9/11 | 21/24 | 11/10 |
| Age (years) | 13 | 15 | 14 | 14 | 12 |
| Histological score | |||||
| 0 | 26 | 30 | – | – | – |
| 1 | – | – | 14 | 25 | 1 |
| 2 | – | – | 6 | 17 | 14 |
| 3 | – | – | – | 3 | 6 |
| Treated | – | 13 | – | 16 | 8 |
| TNF-α (pg/100 µg) | 4·0 | 4·4 | 6·0 | 15·5* | 45·8* |
| (2·1–5·0) | (2·4–6·1) | (2·8–8·8) | (6·0–25·5) | (19·6–61·1) | |
| IL-1β (pg/100 µg) | 1·9 | 2·3 | 6·0* | 12·1* | 27·5* |
| (1·1–3·1) | (1·7–3·4) | (2·7–11·1) | (5·5–24·0) | (14·8–44·1) | |
| IL-1RA (pg/100 µg) | 218 | 248 | 445 | 391 | 930* |
| (145–378) | (133–430) | (202–690) | (242–645) | (385–2980) | |
| IL-1RA/IL-1β | 104 | 118 | 50 | 33* | 29* |
| (60–195) | (83–191) | (39–93) | (25–57) | (20–65) | |
Age and cytokine values are expressed as median (interquartile range).
*
P < 0·05 versus N-IC. Groups: N-IC: non-inflammatory controls; CD−: Crohn's disease with rectal tissue non-involved; IC: inflammatory controls; CD+: Crohn's disease with rectal involvement; UC+: ulcerative colitis with rectal involvement.