Table 2.
TNF-α in colonic explant supernatants cultured for 18 h in the presence of bacterial products
| TNF-α (pg/100 μg) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Group | n | PWM | n | LPS | n | SEB | n | SEA |
| N-IC | 9 | 14·3 (7·0–30·5) | 9 | 3·0 (1·6–6·0) | 12 | 14·6 (10·7–16·6) | 10 | 5·9 (5·6–10·4) |
| CD− | 10 | 16·6 (7·5–36·2) | 10 | 4·6 (1·9–10·0) | 15 | 22·4 (12·8–46·0) | 8 | 11·3 (7·6–32·8) |
| IC | 6 | 23·1 (10·7–31·4) | 12 | 8·0 (4·1–19·0)* | 9 | 47·0 (17·4–107·0)* | 4 | 69·3 (45·1–72·8)* |
| CD+ | 13 | 40·2 (13·0–52·1)* | 15 | 14·1 (8·5–27·5)* | 15 | 55·2 (43·9–65·0)* | 13 | 49·8 (22·2–57·2)* |
| UC+ | 7 | 110·0 (69·6–126·0)* | 7 | 43·8 (22·2–83·1)* | 6 | 61·0 (35·2–106·5)* | 6 | 84·1 (45·8–120·4)* |
Results are expressed as median (IQR)
*
P < 0·05 versus N-IC explants stimulated with the same activator. Groups: N-IC: non-inflammatory controls; CD−: Crohn's disease with rectal tissue noninvolved; IC: inflammatory controls; CD+: Crohn's disease with rectal involvement; UC+: ulcerative colitis with rectal involvement.