Fig. 8.
Inhibition of HIV-1 infection by IL-16 requires Lck kinase. (a) S1T cells (5 × 105) were untreated or pretreated with 5 × 10−9M human recombinant IL-16 for 4 h prior to infection with HIV-1IIIB (moi, 0·3). HIV-1 replication was measured by gag p24 ELISA after 2 days of culture. Results represent the mean p24 antigen level ± SEM of triplicate cultures. P= n.s. (b) In parallel with S1T cells above, Jurkat cells (5 × 105) were untreated or pretreated with 5 × 10−9 M human recombinant IL-16 for 4 h prior to infection with HIV-1IIIB (moi, 0·3). HIV-1 replication was measured by gag p24 ELISA after 2 days of culture. Results represent the mean p24 antigen level ± SEM of triplicate cultures. P-value was determined using a paired Student's t-test.