Fig. 2.

Kinetics of (a) IFN-γ, (b) IL-10 and (c) IL-2 production by PBMC from HSV-infected individuals in AD and NAD categories at various times before and after the onset of a genital HSV recurrence (day 0). PBMC (1 × 10⁶/ml) obtained from patients with AD (n = 17) and NAD (n = 10) were stimulated with HSV-2 antigen for 5 days and the supernatants analysed for IL-2, IL-10 and IFN-γ production by ELISA as described in the legend to Fig. 1 and in Subjects and Methods section. The coefficient of linear regression (P-values) was calculated for each cytokine using the statistical analysis function of Microsoft Excel. (a) P= 0.046; (b) P= 0.71;