Fig. 1.

Anti-CD28/IL-12 synergy drives the proliferation of allogeneic T cells to primary AML blasts. (a) Proliferation, as determined by [³H] thymidine uptake, of allogeneic T cells (2 × 10⁵ cells/well) stimulated with primary AML blasts (2 × 10⁴cells/well) in the presence of anti-CD28 antibody , IL-12 cytokine (▪) or anti-CD28 in combination with IL-12 cytokine (□). Fold increase was calculated relative to the proliferation of T cells stimulated with AML blasts alone. (b) The effect of anti-CD28 on allogeneic T cell response to AML blasts plus IL-12.